DNA replication is a fundamental process essential for bacterial growth and survival. Initiation begins at the chromosomal origin (oriC), where the conserved initiator protein DnaA assembles into an ...

A diagram of the DRT3 system, showing Drt3a in yellow and Drt3b in blue. (Hyunbin Lee) Scientists have just discovered an ...

Scientists are uncovering a deeper layer of DNA biology—where its shape, stiffness, and 3D organization are just as important as its sequence. New tools are mapping how replication starts, how damage ...

The DNA packed inside every human cell contains instructions for life, written in billions of letters of genetic code. Every time a cell divides, the complete code, divided among 46 chromosomes, must ...

DNA’s elegant double helix isn’t just beautiful—it’s a masterclass in precision engineering. From base pairing to semi-conservative replication, every step ensures life’s blueprint is copied ...

A protein that is involved in determining which enzymes cut or unwind DNA during the replication process has been identified. A protein that is involved in determining which enzymes cut or unwind DNA ...

Delve into the field of PARP inhibitors, a class that has gained traction in ovarian, breast, and prostate cancers.

Discovery reshapes understanding of how tumor cells repair broken DNA, pointing toward more precise cancer therapies.

A team of researchers at VCU Massey Comprehensive Cancer Center has identified a new pathway through which mutations in the tumor suppressor p53 gene—found very frequently in human tumors—hijack DNA ...

Drs Ursula A. Matulonis and Joyce F. Liu discuss targeting DNA damage and repair and replication stress in endometrial cancer. Drs Ursula A. Matulonis and Panagiotis A. Konstantinopoulos discuss ...